Aktuelle Publikationen

Titel Datum
The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells. Keywords: HOTAIR; Long noncoding RNA; Bladder cancer; HOX gene Heubach J, Monsior J, Deenen R, Niegisch G, Szarvas T, Niedworok C, Schulz WA, Hoffmann MJ. Mol Cancer. 14(1):108. doi: 10.1186/s12943-015-0371-8. 2015 May 21 2015 May 21
Dietary nitrate is a modifier of vascular gene expression in old male mice. Rammos C, Totzeck M, Deenen R, Köhrer K, Kelm M, Rassaf T, Hendgen-Cotta UB. Oxid Med Cell Longev. 2015;2015:658264. doi: 10.1155/2015/658264. Epub. 2015 Mar 8 2015 Mar 8
Deficiency in Lymphotoxin β Receptor Protects From Atherosclerosis in apoE-Deficient Mice. Keywords: atherosclerosis; chemokine CCL5; inflammation; lymphotoxin beta receptor; monocyte Grandoch M, Feldmann K, Göthert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Köhrer K, Lehr S, Homey B, Pfeffer K, Fischer JW. Circ Res. 2015 Apr 10;116(8):e57-68. doi: 10.1161/CIRCRESAHA.116.305723. Epub. 2015 Mar 4 2015 Mar 4
Target genes of recurrent chromosomal amplification and deletion in urothelial carcinoma. Weilandt M, Koch A, Rieder H, Deenen R, Schwender H, Niegisch G, Schulz WA. Cancer Genomics Proteomics. 11(3):141-53. 2014 May-Jun 2014 May-Jun
Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice. Freudenberger T, Deenen R, Kretschmer I, Zimmermann A, Seiler LF, Mayer P, Heim HK, Köhrer K, Fischer JW. Br J Pharmacol. 2014 Nov;171(22):5032-48. doi: 10.1111/bph.12814. Epub. 2014 Sep 5 2014 Sep 5
Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA. Immunity. 2014 Jun 19;40(6):949-60. doi: 10.1016/j.immuni.2014.05.004. Epub. 2014 Jun 5 2014 Jun 5
16S ribosomal DNA sequence-based identification of bacteria in laboratory rodents: a practical approach in laboratory animal bacteriology diagnostics. Benga L, Benten WP, Engelhardt E, Köhrer K, Gougoula C, Sager M. Lab Anim. 2014 Oct;48(4):305-12. doi: 10.1177/0023677214538240. Epub. 2014 May 29 2014 May 29
β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations. Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse MJ, Schmitt JP. Circ Res. 2014 Jul 7;115(2):227-37. doi: 10.1161/CIRCRESAHA.115.303178. Epub. 2014 May 14 2014 May 14
Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Keywords: Dermal fibroblasts; Ageing; Mitochondrial gene expression; AMP-dependent protein kinase subunits α1 and α2; PPARγ-coactivator 1α; NAD+-dependent deacetylase sirtuin 1; Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Köhrer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F. Exp Gerontol. 2014 Aug;56:59-68. doi: 10.1016/j.exger.2014.03.017. Epub. 2014 Mar 31 2014 Mar 31
Interferon-β induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells. Happold C, Roth P, Silginer M, Florea AM, Lamszus K, Frei K, Deenen R, Reifenberger G, Weller M. Mol Cancer Ther. 2014 Apr;13(4):948-61. doi: 10.1158/1535-7163.MCT-13-0772. Epub. 2014 Feb 13 2014 Feb 13
Age-related vascular gene expression profiling in mice. Keywords: Aging; Vascular; Gene expression; Microarray; Rammos C, Hendgen-Cotta UB, Deenen R, Pohl J, Stock P, Hinzmann C, Kelm M, Rassaf T. Mech Ageing Dev. 2014 Jan;135:15-23. doi: 10.1016/j.mad.2014.01.001. Epub. 2014 Jan 18 2014 Jan 18
Comparing the gene expression profile of stromal cells from human cord blood and bone marrow: lack of the typical "bone" signature in cord blood cells. Bosch J, Houben AP, Hennicke T, Deenen R, Köhrer K, Liedtke S, Kögler G. Stem Cells Int. 2013;2013:631984. doi: 10.1155/2013/631984. Epub. 2013 Sep 16 2013 Sep 16
Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo. Keywords: apoptosis; cell movement; human umbilical vein endothelial cells; nitric oxide; sister-of-mammalian grainyhead protein, human; transcription factors; zebrafish Haendeler J, Mlynek A, Büchner N, Lukosz M, Graf M, Guettler C, Jakob S, Farrokh S, Kunze K, Goy C, Guardiola-Serrano F, Schaal H, Cortese-Krott M, Deenen R, Köhrer K, Winkler C, Altschmied J. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1639-46. doi: 10.1161/ATVBAHA.113.301428. Epub. 2013 May 16 2013 May 16
Neonatal mesenchymal-like cells adapt to surrounding cells. Liedtke S, Freytag EM, Bosch J, Houben AP, Radke TF, Deenen R, Köhrer K, Kögler G. Stem Cell Res. 2013 Jul;11(1):634-46. doi: 10.1016/j.scr.2013.04.001. Epub. 2013 Apr 10 2013 Apr 10
Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. Luca AC, Mersch S, Deenen R, Schmidt S, Messner I, Schäfer KL, Baldus SE, Huckenbeck W, Piekorz RP, Knoefel WT, Krieg A, Stoecklein NH. PLoS One. 2013;8(3):e59689. doi: 10.1371/journal.pone.0059689. Epub. 2013 Mar 26 2013 Mar 26
Host cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis. Hopfe M, Deenen R, Degrandi D, Köhrer K, Henrich B. PLoS One. 2013;8(1):e54219. doi: 10.1371/journal.pone.0054219. Epub. 2013 Jan 11 2013 Jan 11
An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA. Widera M, Erkelenz S, Hillebrand F, Krikoni A, Widera D, Kaisers W, Deenen R, Gombert M, Dellen R, Pfeiffer T, Kaltschmidt B, Münk C, Bosch V, Köhrer K, Schaal H. J Virol. 2013 Mar;87(5):2707-20. doi: 10.1128/JVI.02755-12. Epub. 2012 Dec 19 2012 Dec 19
Immunoregulatory natural killer cells suppress autoimmunity by down-regulating antigen-specific CD8+ T cells in mice. Ehlers M, Papewalis C, Stenzel W, Jacobs B, Meyer KL, Deenen R, Willenberg HS, Schinner S, Thiel A, Scherbaum WA, Ullrich E, Zitvogel L, Schott M. Endocrinology. 2012 Sep;153(9):4367-79. doi: 10.1210/en.2012-1247. Epub. 2012 Jun 25 2012 Jun 25
IGF-IR signaling attenuates the age-related decline of diastolic cardiac function. Moellendorf S, Kessels C, Peiseler L, Raupach A, Jacoby C, Vogt N, Lindecke A, Koch L, Brüning J, Heger J, Köhrer K, Gödecke A. Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E213-22. doi: 10.1152/ajpendo.00538.2011. Epub. 2012 May 15 2012 May 15
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases. Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Köhrer K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A. Leukemia. 2012 May;26(5):963-71. doi: 10.1038/leu.2011.371. Epub. 2012 Jan 6 2012 Jan 6